Comparative genomics and evolution of alternative splicing: the pessimists' science.
نویسندگان
چکیده
Group of Bioinformatics, Vavilov Institute of General Genetics, RAS, Gubkina 3, Moscow 119991, Russia, Institute of Bioinformatics, GSF-National Research Center for Environment and Health, Ingostaedter Landstr.1, Neuherberg 85764, Germany, Institute for Information Transmission Problems, RAS, Bolshoi Karetny pereulok 19, Moscow 127994, Russia, and Faculty of Bioengineering and Bioinformatics, Moscow State University, Vorobievy Gory 1-73, Moscow 119992, Russia
منابع مشابه
Comparative genomics of human stem cell factor (SCF)
Stem cell factor (SCF) is a critical protein with key roles in the cell such as hematopoiesis, gametogenesis and melanogenesis. In the present study a comparative analysis on nucleotide sequences of SCF was performed in Humanoids using bioinformatics tools including NCBI-BLAST, MEGA6, and JBrowse. Our analysis of nucleotide sequences to find closely evolved organisms with high similarity by NCB...
متن کاملThe ASAP II database: analysis and comparative genomics of alternative splicing in 15 animal species
We have greatly expanded the Alternative Splicing Annotation Project (ASAP) database: (i) its human alternative splicing data are expanded approximately 3-fold over the previous ASAP database, to nearly 90,000 distinct alternative splicing events; (ii) it now provides genome-wide alternative splicing analyses for 15 vertebrate, insect and other animal species; (iii) it provides comprehensive co...
متن کاملSACKLER SCHOOL OF MEDICINE DEPARTMENT OF HUMAN GENETICS AND MOLECULAR MEDICINE The characteristics, regulation and evolution of human alternatively spliced exons THESIS SUBMITTED TO THE SENATE OF TEL-AVIV UNIVERSITY FOR THE DEGREE OF "DOCTOR OF PHILOSOPHY" BY
Alternative splicing increases protein diversity by allowing multiple, sometimes functionally distinct proteins to be coded from the same gene. It can be specific to tissues, stress conditions, and developmental and pathological states. Analyses of Expressed Sequence Tags (ESTs), which are currently the most widely used tool for predicting alternative splicing, revealed that this phenomenon is ...
متن کاملA CGL Tutorial
Sequence alignment algorithms have revealed much about evolution at the nucleotide and amino-acid level, but little is yet known about the structural evolution of genes; that is to say, how their intron-exon structures, alternative splicing, and UTRs change overtime. Genome annotations comprise an invaluable resource for such studies because they describe the essential parts of a gene and their...
متن کاملRole of Aberrant Alternative Splicing in Cancer
Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical reviews
دوره 107 8 شماره
صفحات -
تاریخ انتشار 2007